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Aquestive Therapeutics Announces $75M Strategic Funding Agreement with RTW to Support the Potential Launch of ´¡²Ô²¹±è³ó²â±ô³¾â„� (epinephrine) Sublingual Film

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Aquestive Therapeutics (NASDAQ: AQST) has secured a $75 million strategic funding agreement with RTW Investments to support the potential launch of ´¡²Ô²¹±è³ó²â±ô³¾â„�, a sublingual film for emergency treatment of allergic reactions. The funding is contingent on FDA approval and other conditions.

The financing will strengthen Aquestive's balance sheet through 2027 and support the commercialization of Anaphylm, potentially the first oral rescue medication for severe allergic reactions. Under the agreement, RTW will receive a tiered single-digit percentage of annual U.S. net sales, subject to a cap.

Aquestive Therapeutics (NASDAQ: AQST) ha ottenuto un accordo strategico di finanziamento da 75 milioni di dollari con RTW Investments per sostenere il potenziale lancio di ´¡²Ô²¹±è³ó²â±ô³¾â„�, un film sublinguale per il trattamento di emergenza delle reazioni allergiche. Il finanziamento è subordinato all'approvazione della FDA e ad altre condizioni.

Il finanziamento rafforzerà il bilancio di Aquestive fino al 2027 e supporterà la commercializzazione di Anaphylm, potenzialmente il primo farmaco rescue orale per reazioni allergiche gravi. In base all'accordo, RTW riceverà una percentuale scalare a una cifra sulle vendite nette annue negli Stati Uniti, soggetta a un tetto.

Aquestive Therapeutics (NASDAQ: AQST) ha asegurado un acuerdo de financiación estratégica de 75 millones de dólares con RTW Investments para apoyar el posible lanzamiento de ´¡²Ô²¹±è³ó²â±ô³¾â„�, un film sublingual para el tratamiento de emergencia de reacciones alérgicas. La financiación está sujeta a la aprobación de la FDA y otras condiciones.

La financiación reforzará el balance de Aquestive hasta 2027 y respaldará la comercialización de Anaphylm, que podría ser el primer medicamento de rescate oral para reacciones alérgicas graves. Según el acuerdo, RTW recibirá un porcentaje escalonado de un solo dígito de las ventas netas anuales en EE. UU., sujeto a un tope.

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ì´ë²ˆ ìžê¸ˆì€ Aquestiveì� 재무 ìƒíƒœë¥� 2027년까지 강화하고 Anaphylmì� ìƒì—…í™�(잠재ì ìœ¼ë¡� ì¤‘ì¦ ì•Œë ˆë¥´ê¸° ë°˜ì‘ì—� 대í•� 최초ì� 경구 ì‘급 약물)ë¥� ì§€ì›í•  예정입니ë‹�. 계약ì—� ë”°ë¼ RTWëŠ� ì—°ê°„ 미국 ìˆœë§¤ì¶œì˜ ë‹¨ì¼ ìžë¦¬ ìˆ� 계층ë³� 비율ì� ìƒí•œì„ ê¹Œì§€ 수령하게 ë©ë‹ˆë‹�.

Aquestive Therapeutics (NASDAQ: AQST) a obtenu un accord de financement stratégique de 75 millions de dollars avec RTW Investments pour soutenir le lancement potentiel d'´¡²Ô²¹±è³ó²â±ô³¾â„�, un film sublingual destiné au traitement d'urgence des réactions allergiques. Le financement est conditionné à l'approbation de la FDA et à d'autres conditions.

Ce financement renforcera la situation financière d'Aquestive jusqu'en 2027 et appuiera la commercialisation d'Anaphylm, qui pourrait devenir le premier médicament de secours oral contre les réactions allergiques sévères. Selon l'accord, RTW recevra un pourcentage échelonné à un chiffre des ventes nettes annuelles aux États-Unis, soumis à un plafond.

Aquestive Therapeutics (NASDAQ: AQST) hat eine strategische Finanzierungsvereinbarung über 75 Millionen US-Dollar mit RTW Investments abgeschlossen, um den möglichen Launch von ´¡²Ô²¹±è³ó²â±ô³¾â„�, einem sublingualen Film zur Notfallbehandlung allergischer Reaktionen, zu unterstützen. Die Finanzierung steht unter dem Vorbehalt der FDA-Zulassung und weiterer Bedingungen.

Die Finanzierung wird die Bilanz von Aquestive bis 2027 stärken und die Kommerzialisierung von Anaphylm unterstützen, das möglicherweise das erste orale Notfallmedikament für schwere allergische Reaktionen wird. Laut Vereinbarung erhält RTW einen gestaffelten einstelligen Prozentsatz der jährlichen Nettoumsätze in den USA, begrenzt durch eine Obergrenze.

Positive
  • Secured $75 million in strategic funding for Anaphylm launch
  • Financial support extends through 2027
  • Potential to be first-in-class oral rescue medication for anaphylaxis
  • Partnership with established healthcare investor RTW Investments
Negative
  • Funding contingent on FDA approval and other conditions
  • Company must share future revenue through tiered royalty payments
  • Requires refinancing of existing debt as condition

Insights

AQST secures crucial $75M pre-launch funding for Anaphylm, significantly strengthening commercialization potential for this novel epinephrine delivery system.

Aquestive's $75 million strategic funding agreement with RTW Investments represents a significant pre-commercialization boost for Anaphylm, their epinephrine sublingual film for anaphylaxis treatment. This conditional financing—dependent on FDA approval—extends the company's runway through 2027, providing crucial capital for the product launch phase.

The deal structure is noteworthy: RTW receives a tiered single-digit percentage of U.S. net sales with an established cap, a reasonable royalty arrangement that preserves significant revenue potential for Aquestive. This transaction demonstrates strong external validation for Anaphylm's commercial prospects from a sophisticated healthcare investor.

Anaphylm's market positioning as potentially the first oral rescue medication for anaphylaxis could represent a paradigm shift in emergency allergy treatment. The current standard—epinephrine auto-injectors—faces persistent challenges with patient compliance due to bulkiness, fear of needles, and carrying inconvenience. A sublingual film alternative could address these barriers, potentially expanding the addressable market and improving emergency response rates.

This agreement strategically de-risks Aquestive's commercialization pathway, allowing the company to focus on launch execution rather than capital raising during the critical early commercialization period. The endorsement from RTW, a respected life sciences investor, adds credibility to Anaphylm's commercial thesis and may help attract additional strategic partnerships.

  • Anaphylm launch funding of $75 million committed by RTW, subject to FDA approval of Anaphylm and other conditions
  • Strategic financing will further strengthen the Company’s balance sheet in advance of potential commercialization of Anaphylm for the emergency treatment of allergic reactions, including anaphylaxis

WARREN, N.J., Aug. 14, 2025 (GLOBE NEWSWIRE) -- Aquestive Therapeutics, Inc. (NASDAQ: AQST) (“Aquestiveâ€� or the “Companyâ€�), a pharmaceutical company advancing medicines to bring meaningful improvement to patients' lives through innovative science and delivery technologies, today announced a $75 million strategic funding agreement with funds managed by RTW Investments, LP (“RTWâ€�), subject to United States Food and Drug Administration (FDA) approval of ´¡²Ô²¹±è³ó²â±ô³¾â„� (epinephrine) Sublingual Film and other conditions.

“This financing provides critical capital that will support Aquestive Therapeutics through 2027, enabling us to successfully bring Anaphylm to market, if approved by the FDA, and deliver a new treatment option for patients in need,� said Dan Barber, Chief Executive Officer of Aquestive. “We continue to believe Anaphylm, potentially the first and only oral rescue medication for the treatment of severe allergic reactions, including anaphylaxis, can transform how patients carry and access their rescue medication. We are excited to partner with RTW to bring this important medication to patients, if approved by the FDA.�

“We are excited to support Aquestive, and today’s investment reflects our belief in the commercial prospects of Anaphylm as a rescue treatment for patients experiencing a severe allergic reaction, including anaphylaxis,� said Roderick Wong, MD, Managing Partner and Chief Investment Officer of RTW Investments, LP. “We remain committed to helping life science companies bring meaningful innovations, like Anaphylm, to patients, caregivers, and healthcare providers.�

The commercial launch financing will become available upon approval of Anaphylm by the FDA, and satisfaction of certain refinancing and other customary conditions related to the Company’s existing debt. Under the terms of the agreement, RTW will receive a tiered single digit percentage of annual net sales of Anaphylm in the U.S. for the treatment of type I allergic reactions (including anaphylaxis), subject to a cap.

Cantor Fitzgerald & Co acted as exclusive financial advisor to Aquestive on the royalty financing.

About ´¡²Ô²¹±è³ó²â±ô³¾â„� (epinephrine) Sublingual Film
´¡²Ô²¹±è³ó²â±ô³¾â„� (epinephrine) Sublingual Film is a polymer matrix-based epinephrine prodrug product candidate. Anaphylm is similar in size to a postage stamp, weighs less than an ounce, and begins to dissolve on contact. No water or swallowing is required for administration. The packaging for Anaphylm is thinner and smaller than an average credit card, can be carried in a pocket, and is designed to withstand weather excursions such as exposure to rain and/or sunlight. The Anaphylm trade name for AQST-109 has been conditionally approved by the FDA. Final approval of the Anaphylm proprietary name is conditioned on FDA approval of the product candidate.

About Aquestive Therapeutics
Aquestive is a pharmaceutical company advancing medicines to bring meaningful improvement to patients' lives through innovative science and delivery technologies. We are developing orally administered products to deliver complex molecules, providing novel alternatives to invasive and inconvenient standard of care therapies. Aquestive has four commercialized products marketed by its licensees in the U.S. and around the world, and is the exclusive manufacturer of these licensed products. The Company also collaborates with pharmaceutical companies to bring new molecules to market using proprietary, best-in-class technologies, like PharmFilm®, and has proven drug development and commercialization capabilities. Aquestive is advancing a late-stage proprietary product candidate for the treatment of severe allergic reactions, including anaphylaxis, and an earlier stage epinephrine prodrug topical gel product candidate for possible various dermatology conditions, including alopecia areata. For more information, visit Aquestive.com and follow us on LinkedIn.

About RTW Investments, LP
RTW Investments, LP is a New York-based, global, full life-cycle investment firm that focuses on identifying transformational and disruptive innovations across the biopharmaceutical and medical technologies sectors. As a leading partner of industry and academia, RTW combines deep scientific expertise with a solution-oriented investment approach to advance emerging medical therapies by building and supporting the companies and/or academics developing them. For further information about RTW, please visit .

Forward-Looking Statement
Certain statements in this press release include “forward-looking statementsâ€� within the meaning of the Private Securities Litigation Reform Act of 1995. Words such as “believe,â€� “anticipate,â€� “plan,â€� “expect,â€� “estimate,â€� “intend,â€� “may,â€� “will,â€� or the negative of those terms, and similar expressions, are intended to identify forward-looking statements. These forward-looking statements include, but are not limited to, statements regarding the advancement and related timing of our product candidate ´¡²Ô²¹±è³ó²â±ô³¾â„� (epinephrine) Sublingual Film through clinical development and approval by the FDA; the expected plans for regulatory approval and commercialization of Anaphylm in markets outside of the United States, if approved by the applicable regulatory authorities; the potential for Anaphylm to be the first and only orally delivered epinephrine product and its ability change the standard of care; the advancement of the Company’s product candidate AQST-108 through clinical development and approval by the FDA for possible various dermatology conditions including alopecia areata; the potential benefits our products and product candidates could bring to patients; and business strategies, market opportunities, and other statements that are not historical facts.

These forward-looking statements are based on our current expectations and beliefs and are subject to a number of risks and uncertainties that could cause actual results to differ materially from those described in the forward-looking statements. Such risks and uncertainties include, but are not limited to, risks associated with our development work, including any delays or changes to the timing, cost and success of our product development activities and clinical trials and plans, including those relating to Anaphylm and AQST-108; risk of delays in advancement of the regulatory approval process through the FDA of our product candidates, including with respect to the approval of our filed NDA for Anaphylm, or the failure to receive FDA approval at all for any of our product candidates, including Anaphylm and AQST-108; risk of the Company’s ability to generate sufficient clinical data for approval of our product candidates, including with respect to our pharmacokinetic and pharmacodynamic comparability submission for FDA approval of Anaphylm; risk of the Company’s ability to address the FDA’s comments on the Company’s clinical trials and other concerns identified in the FDA’s Type C meeting minutes and filing review letter for Anaphylm, including the risk that the FDA may require additional clinical studies for approval of Anaphylm; risk that the FDA may require that an Advisory Committee be required for the approval of Anaphylm and that the Company is able to address any concerns raised by such Advisory Committee or the FDA after review of the advice from the Advisory Committee; risk of delays in advancement of the regulatory approval process outside the U.S. of our product candidates, including Anaphylm in Canada and the European Union; risk of the success of any competing products, including generics; risks and uncertainties inherent in commercializing a new product (including technology risks, financial risks, market risks and implementation risks and regulatory limitations); risk of sufficient capital and cash resources, including sufficient access to available debt and equity financing, including under our ATM facility, and revenues from operations, to satisfy all of our short-term and longer-term liquidity and cash requirements and other cash needs, at the times and in the amounts needed, including to fund commercialization activities relating to fund future clinical development and commercial activities for our product candidates, including Anaphylm and AQST-108, should these product candidates be approved by the FDA, Health Canada and EMA; risk of eroding market share for Suboxone® and risk as a sunsetting product, which accounts for the substantial part of our current operating revenue; risk of default of our debt instruments; risks related to the outsourcing of certain sales, marketing and other operational and staff functions to third parties; risk of the rate and degree of market acceptance in and outside of the U.S. of Anaphylm and our other product candidates, should these product candidates be approved by the FDA, Health Canada and EMA, and for our licensed products in the U.S. and abroad; risk of the size and growth of our product markets; risk of compliance with all FDA and other governmental and customer requirements for our manufacturing facilities; risks associated with intellectual property rights and infringement claims relating to our products; risk that our patent applications for our product candidates, including for Anaphylm, will not be timely issued, or issued at all, by the U.S. Patent and Trademark Office (USPTO); risk of unexpected patent developments; risk of legislation and regulatory actions and changes in laws or regulations affecting our business including relating to our products and products candidates and product pricing, reimbursement or access therefor; risk of loss of significant customers; risks related to claims and legal proceedings against Aquestive including patent infringement, securities, business torts, investigative, product safety or efficacy and antitrust litigation matters; risk of product recalls and withdrawals; risks related to any disruptions in our information technology networks and systems, including the impact of cybersecurity attacks; risk of increased cybersecurity attacks and data accessibility disruptions due to remote working arrangements; risk of adverse developments affecting the financial services industry; risks related to inflation and rising interest rates; risks related to the impact of the COVID-19 global pandemic and other pandemic diseases on our business; risks and uncertainties related to general economic, political (including the Ukraine and Israel wars and other acts of war and terrorism), business, industry, regulatory, financial and market conditions; risks related to uncertainties about U.S. government initiatives and their impact on our business, including imposition of tariffs and other trade restrictions; and other unusual items; and other uncertainties affecting us including those described in the "Risk Factors" section and in other sections included in the Company’s Annual Report on Form 10-K, Quarterly Reports on Form 10-Q, and Current Reports on Form 8-K filed with the U.S. Securities and Exchange Commission. Given those uncertainties, you should not place undue reliance on these forward-looking statements, which speak only as of the date made. All subsequent forward-looking statements attributable to the Company or any person acting on its behalf are expressly qualified in their entirety by this cautionary statement. The Company assumes no obligation to update forward-looking statements or outlook or guidance after the date of this press release whether as a result of new information, future events or otherwise, except as may be required by applicable law.

PharmFilm® and the Aquestive logo are registered trademarks of Aquestive Therapeutics, Inc. All other registered trademarks referenced herein are the property of their respective owners.

Investor Contact:
Brian Korb
astr partners


FAQ

What is the size of Aquestive Therapeutics' funding agreement with RTW for Anaphylm?

Aquestive Therapeutics secured a $75 million strategic funding agreement with RTW Investments to support the potential launch of Anaphylm.

What are the conditions for AQST to receive the RTW funding?

The funding is contingent on FDA approval of Anaphylm, satisfaction of refinancing conditions related to existing debt, and other customary conditions.

How will RTW be compensated in the AQST Anaphylm agreement?

RTW will receive a tiered single-digit percentage of annual net sales of Anaphylm in the U.S., subject to a cap.

How long will the RTW funding support Aquestive Therapeutics' operations?

The strategic financing will support Aquestive Therapeutics' operations through 2027.

What makes Anaphylm unique in the anaphylaxis treatment market?

Anaphylm is positioned to potentially become the first and only oral rescue medication for the treatment of severe allergic reactions, including anaphylaxis.
Aquestive Therapeutics

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