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HPE Helps Enterprises Drive Agentic and Physical AI Innovation With Systems Accelerated by NVIDIA Blackwell and the Latest NVIDIA AI Models

• HPE will ship HPE ProLiant Compute servers featuring NVIDIA RTX PRO 6000 Blackwell Server Edition GPUs, now with a 2U form factor
• HPE Private Cloud AI accelerates development and deployment with newest NVIDIA AI models and blueprints for agentic AI and physical AI

HOUSTON--(BUSINESS WIRE)-- (NYSE: HPE) today announced significant advancements to its that supports enterprise customers of all sizes throughout the entire AI lifecycle. These developments bolster integration with and bring the newest NVIDIA AI models and to HPE Private Cloud AI, enabling developers to deploy AI applications with ease. HPE will also ship HPE ProLiant Compute servers that feature accelerated computing to advance generative, agentic and physical AI workloads.

HPE ProLiant Compute servers accelerated by NVIDIA RTX PRO 6000 Blackwell GPUs

HPE ProLiant Compute servers accelerated by the NVIDIA Blackwell architecture will be available time-to-market. This includes two NVIDIA RTX PRO Server configurations:

• HPE ProLiant DL385 Gen11 server: Supporting up to two in the new , this air-cooled server is well-suited for datacenters tasked with meeting the growing AI demands of the enterprise.
• HPE ProLiant Compute DL380a Gen12 server: Supporting up to 8 NVIDIA RTX PRO 6000 GPUs in a 4U form factor, this configuration will ship in September.

Purpose-built to handle diverse workloads and meet growing enterprise IT demand for GPU-accelerated compute power, HPE ProLiant Compute servers provide organizations with the flexibility and power to innovate across the enterprise, helping unlock new levels of productivity, security, and operational efficiency. HPE ProLiant Compute Gen12 servers feature multi-layered security with HPE Integrated Lights-Out (iLO) 7 Silicon Root of Trust and a secure enclave that enables tamper-resistant protection and quantum-resistant firmware signing. Centralized, cloud-native lifecycle automation delivered through HPE Compute Ops Management reduces IT hours spent on server management by up to 75% and downtime by 4.8 hours per server annually¹. Target workloads include generative and agentic AI; along with physical AI, including robotics and industrial use cases; visual computing, such as quality control monitoring and autonomous vehicles; simulation; 3D modeling; digital twins; and enterprise applications.

HPE recently announced that will be available later this year. This includes support for NVIDIA RTX PRO 6000 GPUs with HPE ProLiant Compute Gen12 servers, seamless scalability across GPU generations, air-gapped management, and enterprise multi-tenancy.

HPE Private Cloud AI adds support for new NVIDIA reasoning models and video blueprint

HPE Private Cloud AI, a turnkey AI factory solution for the enterprise co-developed with NVIDIA, will support the latest versions of the for agentic AI, vision language model (VLM) for physical AI and robotics, and the (VSS 2.4) to build video analytics AI agents that can extract valuable insights from massive columns of video data. Through continuous co-development between HPE and NVIDIA, HPE Private Cloud AI is uniquely designed to deliver the fastest deployment of and NVIDIA Blueprints鈥攁ccessible by customers through HPE AI Essentials.

Through the deepest integration with NVIDIA AI accelerated computing, networking, and software, HPE Private Cloud AI enables enterprises to harness the full potential of AI faster while maintaining control over their data. Customers can leverage this high-performance solution to manage the surging demand for AI inferencing and accelerate AI production.

Driving the AI Revolution Together

鈥淗PE is committed to empowering enterprises with the tools they need to succeed in the age of AI,鈥� said Cheri Williams, senior vice president and general manager for private cloud and flex solutions at HPE. 鈥淥ur collaboration with NVIDIA continues to push the boundaries of innovation, delivering solutions that unlock the value of generative, agentic and physical AI while addressing the unique demands of enterprise workloads. With the combination of HPE ProLiant servers and expanded capabilities in HPE Private Cloud AI, we鈥檙e enabling organizations to embrace the future of AI with confidence and agility.鈥�

鈥淓nterprises need flexible, efficient infrastructure to keep pace with the demands of modern AI,鈥� said Justin Boitano, vice president of enterprise AI at NVIDIA. 鈥淲ith NVIDIA RTX PRO 6000 Blackwell GPUs in HPE鈥檚 2U ProLiant servers, enterprises can accelerate virtually every workload on a single, unified, enterprise-ready platform.鈥�

Availability

The HPE ProLiant DL385 Gen11 and HPE ProLiant Compute DL380a Gen12 servers featuring NVIDIA RTX PRO 6000 Blackwell Server Edition GPUs are orderable today and will begin shipping worldwide September 2, 2025.

HPE Private Cloud AI support for NVIDIA Nemotron models, Cosmos Reason, and NVIDIA Blueprint for VSS 2.4 will be available during the second half of 2025.

The next generation of HPE Private Cloud AI with NVIDIA RTX PRO 6000 Blackwell Server Edition GPUs will be released in the second half of 2025.

About HPE

HPE (NYSE: HPE) is a leader in essential enterprise technology, bringing together the power of AI, cloud, and networking to help organizations achieve more. As pioneers of possibility, our innovation and expertise advance the way people live and work. We empower our customers across industries to optimize operational performance, transform data into foresight, and maximize their impact. Unlock your boldest ambitions with HPE. Discover more at .

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Cristina Thai

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Source: Hewlett Packard Enterprise